Tools
We combine the best tools in chemistry and biology to study natural products
Natural product biosynthesis requires a broad range of instrumentation. This includes tools for routine molecular biology such as centrifuges and thermocyclers as well as well as tools for routine organic chemistry such as rotovaps and fume hoods. More niche tools include our bioprocess equiment, such as our three 15 L Applikon bioreactors, which allows us to grow dozens of liters of culture in a week. We also have excellent bioanalytical equipment, including a Shimadzu HPLC for preparative purifications, a Thermo LTQ XL mass spectrometer with Vanquish UPLC and an Oxford Nanopore Technologies Promethion sequencer (P2 Solo).
Instruments and Equipment
Shimadzu HPLC
HPLC with photodiode array detector and fraction collector for preparative separations.
Thermo LTQ XL / Vanquish UPLCMS
Unit resolution ion trap spectrometer with UPLC for natural product and enzyme discovery.
Bioreactors
Applikon bioreactors with up to 15 L capacity with controller (IKA and Applikon), features include temperature, dissolved oxygen and pH control.
Nanopore sequencer
Oxford Nanopore Technologies Promethion sequencer, P2 Solo format. Long-read sequencing device for tackling complex animal genomes and metagenomes.
Computational workstation
Computer with 32 core CPU, 256 GB RAM and graphics card for analyzing sequencing data.
Analytical balances
Highly precise balances for measuring tiny amounts of sample.
Laminar flow hood
Flow hood for microbiology work.
Shaking incubators
Three MaxQ 8000 and two MaxQ 6000 shakers for microbiology.
Nanodrop spectrophotometer
Spectrophotometer for measuring DNA and protein at microliter scale.
Water purification system
For generating ultrapure water without ions or organic contaminants.
Photoreactor
Rayonet photoreactor for doing chemical reactions with UVA, UVB and UVC.
Rotovaps
For evaporating solvents.
Speedvac
For evaporating solvents.
Lyophilizer
For evaporating solvents.