Harriet Thompson

"I’m a fourth year PhD student with an undergraduate background in biological target validation of small molecule inhibitors and synthesis of library compounds for the disruption of ß-catenin:BCL-9 protein-protein interactions; and a graduate background in development of a novel class of bioisosteres for phosphotyrosine and novel warheads for lysine-targeted covalent inhibition. My current research focuses on elucidating the cellular targets of Crassin acetate (which is expected to have a covalent mechanism of action - my favorite!) and subsequently derivatizing it to lend better selectivity for targets involved in oncogenic pathways. Outside of the lab, I enjoy playing bass, playing with my cats and freshwater fish, and having ominous feelings that my night queue NMR sample could be degrading in its tube (it’s not)."